Incidence of PVS-induced ventricular tachycardia and acute posterolateral myocardial ischemia-induced lethal ventricular arrhythmias in chloralose-anesthetized dogs with previous anterior myocardial infarction
| Parameter | Microemulsion Vehicle | L-768673 (0.3 μg/kg i.v.) | Timolol (1.0 μg/kg i.v.) | L-768673 (0.3 μg/kg) +Timolol (1.0 μg/kg i.v.) |
|---|---|---|---|---|
| Suppression of PVS-induced ventricular tachyarrhythmia | 1/10 | 3/10 | 4/8 | 8/102-b |
| Time to onset of acute posterolateral ischemia (min) | 50 ± 11 | 49 ± 11 | 43 ± 13 | 56 ± 11 |
| Left circumflex coronary artery thrombus mass (mg) | 3.9 ± 0.8 | 7.7 ± 2.2 | 5.7 ± 1.8 | 17.8 ± 4.72-c |
| Incidence of ischemic lethal ventricular arrhythmias | 8/10 | 6/10 | 6/8 | 3/102-a |
| Underlying anterior myocardial infarct size (% left ventricle) | 25.5 ± 2.9 | 17.2 ± 4.4 | 26.3 ± 3.3 | 22.0 ± 1.3 |
Data are mean ± S.E.M. (n = 8–10).
↵2-a p < 0.05 compared to microemulsion control group by Fisher's exact test.
↵2-b p < 0.01 compared to microemulsion control group by Fisher's exact test.
↵2-c p < 0.01 compared to microemulsion control group by single factor analysis of variance, followed by Fisher's protected least significant difference post hoc test.