Table 2

Maximum survival with different drug applications in mutant mice

Drug	i.p. Administration		Oral Administration
Drug	Dose	p value	Survival	Dose	pvalue	Survival
			%			%
NCS-382	300	<0.0001	61.5
Taurine	250	0.0022	55.6	5000	0.0013	30.8
CGP 35348	300	0.0447	27.3	2000	0.0016	22.2
VGB	25	<0.0001	25	800	<0.0001	50

All dosage units are in terms of mg/kg body weight (for oral administration, assuming an average mutant mouse weight of 10 g with consumption of 4–6 ml of drinking water/day). Mutant mice living beyond 30 days were considered to have survived.