Table 1

Effect of several inhibitors on l-cystine uptake at 5 min by MBEC4 cells

InhibitorsPercentage of Control for [14C]l-Cystine Uptake
147 mM Na+Absence of Na+
Control100 ± 297.9 ± 7.61-a
1 mM l-Cystine6.55 ± 0.421-150 4.68 ± 0.111-150
2.5 mM l-Glutamic acid3.27 ± 0.441-150 6.85 ± 0.321-150
2.5 mM l-Aspartic acid58.4 ± 1.61-150 N.D.
2.5 mMl-α-Aminoadipic acid5.81 ± 0.191-150 N.D.
2.5 mM l-Homocysteic acid2.64 ± 0.261-150 N.D.
2.5 mMl-Quisqualic acid6.35 ± 0.871-150 N.D.
2.5 mMdl-Diaminopimelic acid62.0 ± 1.41-150 N.D.
2.5 mMl-Leucine93.5 ± 14.2N.D.
2.5 mMl-Lysine82.1 ± 0.5N.D.
2.5 mMl-Arginine97.3 ± 6.6N.D.
2.5 mMp-Aminohippuric acid77.6 ± 5.8N.D.
2.5 mM γ-Aminobutyric acid76.5 ± 4.0N.D.

Each value represents the mean ± S.E.M. (n = 3–24).

  • N.D., not determined.

  • ↵1-150  p < 0.001, significantly different from respective controls.

  • ↵1-a Compared with control of 147 mM Na+.