Effects of cilomilast on airway reactivity and lung inflammation in allergic guinea pigs
| Treatment | Cilomilast | Airway Reactivity PD100 | BAL Cells × 106/ml | |
|---|---|---|---|---|
| Cells | Eosinophils | |||
| mg/kg | μg ACh/kg | |||
| Saline | 0 | 10.8 ± 1.9 | 0.6 ± 0.2 | 0.1 ± 0 |
| OVA | 0 | 5.4 ± 1.0 | 3.3 ± 0.5 | 1.1 ± 0.1 |
| OVA | 3 | 8 ± 1.8 | 3.4 ± 0.3 | 1.3 ± 0.1 |
| OVA | 30 | 9.9 ± 1.06-a | 3.0 ± 0.4 | 1.1 ± 0.2 |
Airway reactivity and BAL cells were measured as described in Table 4.
OVA, ovalbumin.
↵6-a p < 0.05 compared with OVA (n = 6 animals/group).