Effects of DHX and PrDHX on dopamine synthesis in reserpine-treated rats
| Drug | Conc. | Drug Alone | +0.5 μM Spiperone |
|---|---|---|---|
| μM | % control | ||
| Spiperone | 0.5 | 93.8 ± 5.0 | N.D. |
| DHX | 1.0 | 55.0 ± 3.84-150 | 44.3 ± 3.0 |
| DHX | 10.0 | 17.7 ± 1.54-150 | N.D. |
| PrDHX | 0.1 | 105.3 ± 4.3 | N.D. |
| PrDHX | 1.0 | 53.6 ± 5.64-150 | 60.2 ± 5.5 |
| PrDHX | 10.0 | 12.7 ± 5.84-150 | N.D. |
Data were pooled (n ≥ 3) and expressed as mean ± S.E.M. percentage of corresponding basal control values (16.9 pmol of14CO2/30 min/mg protein).
N.D., not determined.
↵4-150 P < 0.001 versus control.