Dopamine receptor characteristics of DHX, PrDHX, and related drugs in rat striatum
| Radioligand and Conditions | vs. [3H]SCH23390 | vs. [3H]Spiperone | vs. [3H]Spiperone +GppNHp | vs. [3H]NPA | ||||
|---|---|---|---|---|---|---|---|---|
| K0.5 | nH | K0.5 | nH | K0.5 | nH | K0.5 | nH | |
| nM | nM | nM | nM | |||||
| DHX | 6.2 ± 1.1 | 0.70 ± 0.02 | 50 ± 18 | 0.68 ± 0.09 | 123 ± 33 | 0.67 ± 0.05 | 14 ± 3 | 0.82 ± 0.05 |
| PrDHX | 320 ± 88 | 0.82 ± 0.05 | 20 ± 5 | 0.66 ± 0.02 | 64 ± 3 | 0.63 ± 0.04 | 6.5 ± 0.6 | 0.93 ± 0.08 |
| Quinpirole | >1000 | N.D. | 48 ± 14 | 0.68 ± 0.03 | N.D. | N.D. | N.D. | N.D. |
| CPZ | N.D. | N.D. | 1.2 ± 0.2 | 0.93 ± 0.06 | 1.4 ± 0.3 | 1.06 ± 0.11 | 0.72 ± 0.04 | 0.93 ± 0.07 |
| SCH23390 | 0.34 ± 0.02 | 0.98 ± 0.04 | >5000 | N.D. | N.D. | N.D. | N.D. | N.D. |
See Experimental Procedures for details. Values are expressed as mean ± S.E.M. from at least three independent experiments.
N.D., not determined; CPZ, chloropromazine.