Comparison of fibrosis (FI), AAG tissue level, MP concentration, CR, and P450 content in various animal models (mean ± S.D.,n = 6)
| Animal Model | FI | AAG1-a | MP | CR | P450 |
|---|---|---|---|---|---|
| % | mg/ml | mg/g liver | mg/g liver | nmol/mg protein | |
| Normal control | 0.51 ± 0.23 | 0.35 ± 0.04 | 9.40 ± 0.27 | 186.40 ± 24.18 | 0.56 ± 0.25 |
| CCl4 control | 0.87 ± 0.24 | 0.38 ± 0.05 | 8.16 ± 1.09 | 195.95 ± 19.93 | 0.68 ± 0.05 |
| Alcohol control | 0.43 ± 0.17 | 0.32 ± 0.03 | 7.82 ± 0.57 | 177.60 ± 24.83 | 0.55 ± 0.11 |
| CCl4-treated | 6.07 ± 1.411-b 1-c | 0.22 ± 0.04 | 5.42 ± 1.31 | 129.33 ± 36.89 | 0.14 ± 0.08 |
| Alcohol-treated | 3.11 ± 1.32 | 0.55 ± 0.061-d 1-e | 11.06 ± 0.381-f 1-g | 219.63 ± 22.381-h | 1.02 ± 0.141-i 1-j |
↵1-a Homogenate of 1 g of liver and 1 ml of buffer.
↵1-b p < 0.05 versus alcohol-treated rats.
↵1-c p < 0.001 versus controls.
↵1-d p < 0.05 versus controls.
↵1-e p < 0.01 versus CCl4-treated rats.
↵1-f p < 0.05 versus controls.
↵1-g p < 0.001 versus CCl4-treated rats.
↵1-h p < 0.05 versus CCl4-treated rats.
↵1-i p < 0.01 versus controls.
↵1-j p < 0.001 versus CCl4-treated rats.