Table 3

Effects of SSR180575 on pregnenolone concentrations in rat plasma, brain, and sciatic nerve

	Control ⁺ Vehicle	Trilostane ⁺Vehicle	Trilostane ⁺ SSR180575
Plasma (ng/ml)	0.86 ± 0.16	65.84 ± 7.38^3-165	96.66 ± 17
Brain (ng/g)	11.14 ± 1.4	382 ± 77.59^3-165	713 ± 77.23^3-159
Sciatic nerve (ng/g)	7.68 ± 0.40	218.87 ± 29.15^3-165	440.50 ± 12.82^3-167

Rats were injected with SSR180575 at 3 mg/kg i.p. or vehicle (C), 15 min after trilostane (10 mg/kg i.p.). Tissues were removed 15 min after SSR180575 treatment. Data are means ± S.E.M. of data obtained from 8 to 10 rats per group.

↵3-165 p < 0.001 trilostane-treated group versus control.
↵3-167 p < 0.01,
↵3-159 p < 0.05, trilostane + SSR180575 versus trilostane-treated group (Newman-Keuls test).