[11C]WAY-100635 BP derived from baseline, 2, and 24 h postdrug PET scans
| Group | Subject | Autoreceptor BP | Occupancy % | |||
|---|---|---|---|---|---|---|
| Baseline | 2 h | 24 h | 2 h | 24 h | ||
| 40 mg | 1 | 3.8 | 1.8 | 52 | ||
| 2 | 3.7 | 1.1 | 2.6 | 71 | 29 | |
| 3 | 5.0 | 1.6 | 3.7 | 69 | 27 | |
| 4 | 3.5 | 1.1 | 69 | |||
| 20 mg | 5 | 3.2 | 3.2 | 1 | ||
| 6 | 4.3 | 1.5 | 2.9 | 66 | 32 | |
| 7 | 4.7 | 1.8 | 61 | |||
| 8 | 3.3 | 1.6 | 52 | |||
| 10 mg | 9 | 4.2 | 3.5 | 16 | ||
| 10 | 4.2 | 4.2 | 0 | |||
| 11 | 3.8 | 4.3 | −12 | |||
| 12 | 5.6 | 3.6 | 36 | |||
| Test-retestn = 15 | Scan 1 4.5 ± 0.6 | Scan 2 4.6 ± 0.6 | Difference ± S.D. −2.1 ± 17.9 | |||
| Postsynaptic Receptor BP | Occupancy % | |||||
|---|---|---|---|---|---|---|
| 40 mg | 1 | 3.0 | 1.5 | 49 | ||
| 2 | 5.7 | 1.6 | 3.2 | 72 | 43 | |
| 3 | 6.0 | 1.7 | 4.4 | 71 | 27 | |
| 4 | 3.7 | 1.3 | 66 | |||
| 20 mg | 5 | 3.9 | 2.8 | 28 | ||
| 6 | 4.6 | 2.1 | 3.6 | 54 | 22 | |
| 7 | 4.5 | 2.0 | 54 | |||
| 8 | 5.3 | 2.4 | 56 | |||
| 10 mg | 9 | 5.5 | 4.0 | 27 | ||
| 10 | 5.4 | 4.9 | 10 | |||
| 11 | 4.5 | 4.8 | −7 | |||
| 12 | 6.1 | 3.1 | 49 | |||
| Test-retestn = 15 | Scan 1 | Scan 2 | Difference ± S.D. | |||
| 5.0 ± 0.6 | 5.3 ± 0.6 | −6.0 ± 11.4 | ||||