Table 2

Values of negative logarithm of IC₅₀S values (plC₅₀) and maximum percentage inhibition (I_MAX) of [³H] NMS binding by xanomeline obtained by nonlinear regression analysis of data from Fig. 4

[³H]NMS Concentration	Simultaneous Presence of Xanomeline		Preincubated with Xanomeline
[³H]NMS Concentration	plC₅₀	I_MAX	plC₅₀	I_MAX
125 pM	7.10 ± 0.02	99.7 ± 0.7	5.12 ± 0.03	98.9 ± 0.9
250 pM	7.05 ± 0.03	99.5 ± 0.8	5.08 ± 0.02	99.7 ± 0.6
500 pM	7.00 ± 0.03	99.7 ± 0.8	5.04 ± 0.03	91.7 ± 0.9
1000 pM	6.73 ± 0.02	99.7 ± 0.7	4.77 ± 0.02	91.9 ± 0.9

Equation 3 was fitted to the data sets. Data are presented as means ± S.D. of three to four experiments.