Naltrexone (mg/kg) | |||||||||
---|---|---|---|---|---|---|---|---|---|
0.00032 | 0.001 | 0.0032 | 0.01 | 0.032 | 0.10 | 0.32 | 1.0 | ||
Tests (mg/kg) | |||||||||
Saline | 1.54 ± 0.38 | 1.61 ± 0.33 | 1.64 ± 0.43 | 1.55 ± 0.55 | 1.97 ± 0.30 | ||||
Cocaine | |||||||||
0.1 | 1.96 ± 0.36 | 1.62 ± 0.30 | 1.61 ± 0.46 | 1.66 ± 0.58 | 1.36 ± 0.16 | 1.29 ± 02-150 | |||
0.32 | 1.83 ± 0.37 | 1.71 ± 0.36 | 1.71 ± 0.37 | 1.81 ± 0.64 | 2.20 ± 0.05 | 2.37 ± 0 | 2.31 ± 0 | 2.80 ± 0 | |
1.0 | 1.58 ± 0.62 | 1.58 ± 0.69 | 1.70 ± 0.45 | 1.94 ± 0.64 | 1.49 ± 0.77 | 2.06 ± 0.09 | 2.35 ± 0.20 | 2.07 ± 0.27 | |
Amphetamine | |||||||||
0.1 | 1.95 ± 0.41 | 1.85 ± 0.43 | 1.84 ± 0.40 | 1.99 ± 0.60 | 2.22 ± 0.64 | 2.80 ± 0 | 2.60 ± 0 | 2.61 ± 0 | |
0.32 | 2.01 ± 0.49 | 1.96 ± 0.67 | 1.93 ± 0.78 | 2.24 ± 0.77 | 2.42 ± 0.97 | 3.13 ± 0 | 3.21 ± 0 | 3.13 ± 0 | |
1.0 | 1.44 ± 0.27 | 1.23 ± 0.34 | 1.84 ± 0.45 | 1.73 ± 0.41 | 1.62 ± 0.29 | 1.88 ± 0.54 | 1.92 ± 0.83 | 1.67 ± 1.08 | |
Haloperidol | |||||||||
0.01 | 1.54 ± 0.38 | 1.35 ± 0.47 | 1.27 ± 0.51 | 1.36 ± 0.33 | 1.01 ± 0.48 | 0.65 ± 0.35 | |||
0.032 | 1.58 ± 0.65 | 1.26 ± 0.41 | 1.26 ± 0.84 | 0.44 ± 0.17 | |||||
Sulpiride | |||||||||
1 | 1.54 ± 0.55 | 1.54 ± 0.47 | 1.61 ± 0.51 | 1.45 ± 0.66 | 1.49 ± 0.69 | ||||
3.2 | 1.54 ± 0.46 | 1.57 ± 0.47 | 1.56 ± 0.62 | 1.43 ± 0.65 | 2.12 ± 0 | ||||
10 | 1.76 ± 0.34 | 1.77 ± 0.43 | 1.64 ± 0.48 | 1.59 ± 0.69 | 2.16 ± 0 | ||||
Propranolol | |||||||||
0.32 | 1.66 ± 0.44 | 1.54 ± 0.20 | 1.71 ± 0.41 | 1.04 ± 0.36 | |||||
1.0 | 1.38 ± 0.50 | 1.35 ± 0.52 | 1.30 ± 0.40 | 0.84 ± 0.04 | |||||
3.2 | 1.38 ± 0.42 | 1.47 ± 0.44 | 1.45 ± 0.55 | 1.55 ± 0.53 | 1.00 ± 0.57 | ||||
Clonidine | |||||||||
0.001 | 1.72 ± 0.38 | 1.61 ± 0.48 | 1.57 ± 0.43 | 1.56 ± 0.64 | 1.34 ± 0.86 | ||||
0.0032 | 1.57 ± 0.36 | 1.51 ± 0.63 | 1.21 ± 0.65 | 1.74 ± 0.53 | 0.94 ± 0 | ||||
0.01 | 1.36 ± 0.51 | 1.30 ± 0.51 | 1.46 ± 0.50 | 1.47 ± 0.64 | 0.74 ± 0 | ||||
0.032 | 1.13 ± 0.10 | 1.11 ± 0.21 | 0.91 ± 0.40 | 0.75 ± 0.24 | 0.73 ± 0 | ||||
Desipramine | |||||||||
0.1 | 1.83 ± 0.76 | 1.73 ± 0.90 | 1.65 ± 1.06 | 1.81 ± 1.01 | 1.80 ± 0.99 | ||||
0.32 | 1.66 ± 0.44 | 1.42 ± 0.56 | 1.38 ± 0.61 | 1.88 ± 0.62 | |||||
1.0 | 1.48 ± 0.28 | 1.46 ± 0.31 | 1.52 ± 0.41 | 1.58 ± 0.62 | 0.67 ± 0 | ||||
3.2 | 1.72 ± 0.33 | 1.52 ± 0.36 | 1.45 ± 0.57 | 1.16 ± 0.17 | |||||
Imipramine | |||||||||
1 | 1.90 ± 0.43 | 1.64 ± 0.53 | 1.53 ± 0.69 | 1.73 ± 0.71 | 1.63 ± 0.57 | ||||
3.2 | 1.45 ± 0.15 | 1.56 ± 0.59 | 1.35 ± 0.31 | 1.51 ± 0.66 | 0.81 ± 0.44 | 1.77 ± 0 | 1.51 ± 0 | 1.54 ± 0 | |
10 | 1.21 ± 0.77 | 1.15 ± 0.69 | 1.68 ± 0.36 | 1.26 ± 0.84 | 1.22 ± 1.04 | 1.63 ± 0 | 1.88 ± 0 | 1.64 ± 0 |
Data are presented as means ± S.D.
↵2-150 When S.D. = 0, then n = 1 for that dose of naltrexone.