Animal | Model Parameters | Derived Parameters | |||||
---|---|---|---|---|---|---|---|
Vc | kcel | kcp | kpc | Clearance | Vss | Half-Life3-a | |
l/kg | h−1 | h−1 | h−1 | l/kg/h | l/kg | h | |
85Z | 0.13 | 4.7 | 5.2 | 2.1 | 0.60 | 0.44 | 0.76 |
H090 | 0.43 | 1.1 | 2.1 | 4.6 | 0.50 | 0.64 | 0.94 |
9SL | 0.48 | 1.6 | 0.9 | 1.4 | 0.79 | 0.79 | 0.99 |
Mean | 0.35 | 2.5 | 2.7 | 2.7 | 0.63 | 0.62 | 0.90 |
S.D. | 0.19 | 1.9 | 2.2 | 1.7 | 0.15 | 0.18 | 0.12 |
CV (%) | 55 | 78 | 81 | 63 | 24 | 29 | 13 |
Model fitted parameters were Vc (volume of the central compartment), kcel (first order elimination rate constant), kcp and kpc(first order exchange rate constants describing the movement of drug from the central (c) to peripheral (p) and peripheral to central compartments). Vss (steady-state volume of distribution), clearance, and half-lives were derived from the model-fitted parameters.
CV, coefficient of variation.
↵3-a Elimination (β) half-life.