Inhibitory binding constant for CRF, CRF-related peptides, and CRF receptor antagonists used in this study
| Ki1-a | References | |||
|---|---|---|---|---|
| CRF1 | CRF2α | CRF2β | ||
| nM | ||||
| CRF (rat/human) | 2 | 44 | 30.7 | Behan et al., 1996; Perrin et al., 1999 |
| CRF (ovine) | 1 | 184 | 162.4 | Behan et al., 1996 |
| Ucn II (mice) | >100 | 2.1 | 0.66 | Lewis et al., 2001 |
| Ucn III (mice) | >100 | 5.0 | 1.8 | Lewis et al., 2001 |
| Astressin | 2.0 | 1.5 | 1.0 | Perrin et al., 1999 |
| Antisauvagine-30 | 370 | 0.3 | Eckart et al., 2001 | |
| NBI-27914 | 1.9 | >10 μM | Maciejewski-Lenoir et al., 2000 | |
| CP-154,526 | 2.7 | >10 μM1-b | Schulz et al., 1996 | |