Table 1

Disposition kinetics of deuterium-labeled nicotine and cotinine during pregnancy and postpartum

Nicotine-d2Cotinine-d4
PregnantPostpartumPregnantPostpartum
CLT(ml/min/kg)27.01-160 16.91.461-165 0.62
(21.9–31.3)(14.4–19.4)(0.9–2.0)(0.47–0.77)
CLNR(ml/min/26.61-160 16.21.21-150 0.5
 kg)(21.3–31.9)(13.4–18.9)(0.5–1.9)(0.2–0.7)
CLR (ml/min/kg)0.30.70.30.2
(0.17–0.43)(0.16–1.25)(0.12–0.69)(0.02–0.37)
Embedded Image (min)971115271-160 998
(82–112)(97–124)(332–723)(885–1141)
fNIC→COT 76%78%
(62–89)(69–87)
CLNIC→COT (ml/20.11-160 13.1
 min/kg)(15.3–24.9)(11.3–14.9)
  • CLT, total clearance; CLNR, nonrenal clearance; CLR, renal clearance; Embedded Image , half-life; fNIC→COT, percentage of dose of nicotine converted to cotinine; CLNIC→COT, clearance of nicotine via cotinine pathway.

  • 1-150P < 0.05;

  • 1-160P< 0.01;

  • 1-165P < 0.001; mean (95% confidence intervals).