Potency of methylphenidate and analogs for producing cocaine-like discriminative effects
| Compound | ED50 (95% Confidence Limits)4-a | Relative Potency4-b | |
|---|---|---|---|
| mg/kg | μmol/kg | ||
| 3,4CTMP | 0.38 (0.2–0.73) | 0.43 (0.13–1.36)c | 7.98 |
| 4FTMP | 0.26 (0.18–0.36) | 1.03 (0.72–1.43)c d | 3.33 |
| 3CTMP | 0.38 (0.20–0.73) | 1.42 (0.75–2.73)c d e | 2.42 |
| 4ATMP | 0.39 (0.09–1.79) | 1.57 (0.36–7.22)c d e | 2.18 |
| TMP | 0.80 (0.61–1.05) | 3.43 (2.62–4.51)d e f | 1.00 |
| 4MeTMP | 1.15 (0.25–5.33) | 4.65 (1.01–21.6)e f | 0.74 |
| 3CTMPNMe | 2.004-150 | 7.104-150 | 0.48 |
| Cocaine | 2.58 (2.03–3.28) | 8.45 (6.66–10.8) | 0.41 |
| TROMeNBn | 8.28 (2.46–27.9) | 26.7 (7.94–90.0)g | 0.13 |
| TROHNBn | 9.404-150 | 31.64-150 | 0.11 |
| 4MeTMPNMe | 9.06 (3.24–25.4) | 34.7 (12.4–97.3)g | 0.10 |
| TMPNMe | 11.4 (3.47–37.2) | 46.1 (14.0–151)g | 0.07 |
| TMPNBn | >30 | >92 | <0.04 |
↵4-a Dose resulting in selection of the cocaine-appropriate choice lever in an average of 10 trials per session [n = 5 for all drugs except TROHNBn (n = 4) and cocaine (n = 23)].
↵4-b Potency relative to methylphenidate, based upon ED50 values (μmol/kg).
c–g ED50 values that do not have a superscript in common are significantly different from each other, p < 0.05.
↵4-150 Estimated from group means and not included in the ANOVA of ED50 values.