Pharmacodynamic secondary parameters for FTY720 in cynomolgus monkeys
| Dose | Males | Females | ||||
|---|---|---|---|---|---|---|
| Lymphocyte | B Cell | T Cell | Lymphocyte | B Cell | T Cell | |
| Blood ABEC (×100 cells × h/μl) | ||||||
| 0.1 mg/kg p.o. | 3917 | 2394 | 2923 | 4155 | 427 | 3494 |
| 1.0 mg/kg p.o. | 9261 | 4588 | 6834 | 9627 | 1209 | 7897 |
| 0.1 mg/kg i.v. | 5216 | 2922 | 3866 | 4943 | 543 | 4138 |
| Blood ABEC/AUC (×108 cells/μg) | ||||||
| 0.1 mg/kg p.o. | 64.25 | 39.27 | 47.95 | 49.36 | 5.07 | 41.51 |
| 1.0 mg/kg p.o. | 15.19 | 7.53 | 11.21 | 11.44 | 1.44 | 9.38 |
| 0.1 mg/kg i.v. | 27.02 | 15.24 | 20.17 | 26.31 | 2.89 | 22.02 |
| Mean reduction percentage of peripheral counts (%) | ||||||
| 0.1 mg/kg p.o. | 1.26 | 7.07 | 0.052 | 2.04 | 7.83 | 0.039 |
| 1.0 mg/kg p.o. | 2.79 | 12.83 | 0.114 | 4.40 | 21.68 | 0.082 |
| 0.1 mg/kg i.v. | 1.66 | 8.58 | 0.069 | 2.42 | 9.90 | 0.046 |