Pharmacokinetic parameters (CV%) for FTY720 in cynomolgus monkeys
| Parameters | Males | Females |
|---|---|---|
| Fitted from i.v. data | ||
| C 1(μg/l) | 191.0 (18.5) | 125.4 (10.9) |
| λ1(h−1) | 9.773 (12.2) | 7.284 (8.3) |
| C 2 (μg/l) | 11.1 (9.2) | 7.88 (7.5) |
| λ2 (h−1) | 0.200 (12.6) | 0.164 (11.5) |
| C 3(μg/l) | 2.60 (12.2) | 2.70 (9.2) |
| λ3(h−1) | 0.022 (6.7) | 0.022 (5.0) |
| AUC (μg × h/l) | 191.7 (2.9) | 187.9 (2.0) |
| CL (l/h/kg) | 0.522 (2.9) | 0.532 (2.0) |
| V c(l/kg) | 0.487 (17.3) | 0.735 (10.1) |
| V ss (l/kg) | 14.9 (5.5) | 16.6 (3.7) |
| t 1/2 (h) | 30.8 (6.7) | 31.6 (5.0) |
| Fitted from p.o. data | ||
| k a(h−1) | 0.0524 (10.2) | 0.0609 (6.7) |
| F (%) | 31.8 (7.3) | 44.8 (4.4) |
| T lag(h) | 0.49 (0.5) | 0.42 (3.6) |