Table 3

Protective effects of M40403 and SN50 on NMDA-induced alterations in LDH release and MTT metabolism

	LDH Release (O.D., 490–605 nm)		MTT Loss (O.D., 595 nm) 4 h
	2 h	4 h	MTT Loss (O.D., 595 nm) 4 h
Control	0.52 ± 0.02	0.46 ± 0.01	0.61 ± 0.03
NMDA (300 μM)	0.87 ± 0.11^3-150	1.42 ± 0.11^3-150	0.26 ± 0.02^3-150
NMDA ⁺ SN50 (2.5 μM)	0.72 ± 0.02	0.57 ± 0.02	0.66 ± 0.04
NMDA ⁺ SN50 control	0.76 ± 0.06^3-150	1.30 ± 0.10^3-150	0.31 ± 0.02^3-150
NMDA ⁺ M40403 (2.5 μM)	0.72 ± 0.03	0.57 ± 0.02	0.62 ± 0.05
NMDA ⁺ M40404 (2.5 μM)	0.78 ± 0.05^3-150	1.49 ± 0.09^3-150	0.25 ± 0.03^3-150

Neither SN50, SN50 control peptide, M40403, or M40404 had any effect on either LDH release or MTT metabolism when added alone (data not shown).

O.D., optical density.
↵3-150 P < 0.05 (one-way ANOVA with Tukey's test).