Table 2

AUC and clearances of ¹¹¹In-labeled succinylated proteins in mice after intravenous injection at the doses of 0.1, 1, 10, and 20 mg/kg

Compound	Dose	AUC	Clearance
Compound	Dose	AUC	CL_total	CL_liver	CL_kidney	CL_urine
	mg/kg	hr · % of dose/ml	ml/hr
SOD	0.1	6.83	14.6	0.04	13.0	0.18
	20	6.97	14.3	0.03	5.20	3.56

Suc₉-SOD	0.1	5.73	17.5	0.05	13.6	0.74
	1	4.88	20.5	0.06	13.5	2.59
	10	5.84	17.1	0.04	4.45	5.30
	20	4.75	21.0	0.04	4.73	8.93

Suc₂₂-SOD	0.1	4.61	21.7	1.04	2.98	4.10
	1	3.48	28.7	1.19	2.51	7.33
	10	3.42	29.2	1.06	3.49	5.56
	20	4.34	23.1	0.08	2.86	7.37

BSA	0.1	145.96	0.69	0.002	0.020	0.002
	20	144.97	0.69	0.013	0.024	0.002

Suc₂₀-BSA	0.1	144.93	0.69	0.42	0.03	0.006
	1	201.61	0.50	0.29	0.04	0.005
	10	85.69	1.17	0.20	0.08	0.02
	20	134.95	0.74	0.20	0.06	0.01

Suc₂₈-BSA	0.1	6.46	15.5	9.35	1.23	0.39
	1	16.21	6.17	3.67	0.14	0.02
	10	44.74	2.24	0.81	0.23	0.11
	20	65.66	1.52	0.66	0.17	0

Suc₄₀-BSA	0.1	1.54	64.9	48.0	1.82	0.17
	1	4.34	23.0	14.4	0.94	0.26
	10	22.03	4.54	2.22	0.49	0.03
	20	27.83	3.59	1.46	0.60	0.04

Suc₄₆-BSA	0.1	0.71	140.5	72.2	3.46	1.14
	1	4.31	23.2	12.5	1.07	1.69
	10	23.70	4.22	1.37	0.93	0.54
	20	20.44	4.89	1.53	1.04	0.24

Suc₅₄-BSA	0.1	0.71	141.5	69.4	5.59	2.31
	1	2.95	33.9	14.7	2.63	1.31
	10	22.20	5.40	0.81	1.20	0.29
	20	23.29	4.29	0.35	1.42	0.25

IgG	0.1	138.52	0.72	0.03	0.02	0.056
	20	250.01	0.40	0.02	0.01	0.046

Suc₂₂-IgG	0.1	164.58	0.61	0.04	0.02	0.006
	1	237.12	0.42	0.03	0.02	0.005
	10	213.69	0.46	0.04	0.02	0.003
	20	215.84	0.46	0.04	0.02	0.02

Suc₅₀-IgG	0.1	6.16	16.2	7.39	0.64	0.50
	1	18.76	5.33	2.44	0.22	0.10
	10	47.35	2.11	0.84	0.10	0.04
	20	34.91	2.86	0.07	0.07	0.02

AUC and clearances were calculated from experimental data shown in Fig.2.