Drug glucuronidation by human tissue microsomes
| Compound | Hepatic | Intestinal | Renal | Total | ||
|---|---|---|---|---|---|---|
| CLint | CL | CLint | CL | CL | CL | |
| μl/min/mg | ml/min/kg | μl/min/mg | ml/min/kg | ml/min/kg | ml/min/kg | |
| Codeine | 0.41, 0.48 | 0.41 | N.D. | 0 | — | 0.41 |
| Ethinylestradiol | 0.54, 0.76 | 0.05 | 1.3 ± 0.64 | 0.01 | N.D. | 0.07 |
| Furosemide | 0.13, 0.12 | 0.007 | 0.07 ± 0.03 | 0.0004 | — | 0.007 |
| Gemfibrozil | 2.4 ± 0.3 | 0.20 | 1.83 ± 0.28 | 0.02 | 0.21 | 0.42 |
| Imipramine | 0.39, 0.41 | 0.30 | — | — | 0.02 | 0.32 |
| Ketoprofen | 0.23, 0.21 | 0.02 | 0.20 ± 0.03 | 0.002 | 0.06 | 0.08 |
| Morphine | 2.0, 1.9 | 1.3 | N.D. | 0 | 0.47 | 1.8 |
| Naloxone | 0.55 ± 0.1 | 0.37 | 0.21 ± 0.07 | 0.01 | 0.43 | 0.81 |
| Naproxen | 0.38 ± 0.04 | 0.01 | 0.31 ± 0.08 | 0.001 | 0.01 | 0.02 |
| Propofol | 1.4, 3.3 | 0.83 | 1.1 ± 0.18 | 0.04 | 1.3 | 2.2 |
| Valproic acid | 0.21, 0.19 | 0.03 | 0.06 ± 0.02 | 0.001 | 0.02 | 0.06 |
CLint estimates for liver are reproduced from Soars et al. (2001). Renal CL was scaled from CLint estimates obtained previously (Soars et al., 2001). Values for intestine are mean ± S.D. obtained from three separate experiments. Scaled CL was determined using the well stirred model (see Materials and Methods).
N.D., below the level of detection (8 pmol/min/mg); —, not determined.