Summary of compositions of morphine formulations administered to sheep
| Formulation | Morphine HCl | Chitosan Glutamate | Chitosan (XL-CHI MS) | SMS | LPC | Volume/kg or Weight/kg Administered |
|---|---|---|---|---|---|---|
| mg | ||||||
| 1. i.v. Sol | 0.1 | 0.125 ml | ||||
| 2. IN Sol | 0.3 | 0.01 ml | ||||
| 3. IN Sol +CHI | 0.3 | 0.05 | 0.01 ml | |||
| 4. IN PWD XL-CHI | 0.3 | 2.0 | 2.3 mg | |||
| 5. IN PWD SMS +LPC | 0.3 | 2.0 | 0.2 | 2.5 mg | ||
Doses are given on the basis of per kilogram sheep.
CHI, chitosan glutamate; IN, intranasal; PWD, powder; Sol, solution; XL-CHI, cross-linked chitosan microspheres.