Displacement of radiolabeled selective agonists by selective opioid receptor ligands
| Drug | [3H]-DAMGO | [3H]-U65953 | [3H]-DPDPE | |||
|---|---|---|---|---|---|---|
| Ki | 95% CI | Ki | 95% CI | Ki | 95% CI | |
| nM | nM | nM | ||||
| μ Ligands | ||||||
| DAMGO | 12.2 | (7.77–19.3) | 1561 | (374–1630) | 2637 | (1297–5363) |
| Morphine | 2.68 | (1.28–5.60) | 14180 | (2683–74960) | 16.8 | (8.18–34.6) |
| β-FNA | 2.91 | (1.27–6.64) | 5921 | (2264–17820) | 97 | (43.6–219) |
| κ Ligands | ||||||
| U65953 | 16790 | (8223–34230) | 7.2 | (4.87–10.6) | 2783 | (571–13560) |
| CI977 | 474 | (270–828) | 6.2 | (3.26–11.8) | 4812 | (1793–12910) |
| Nor-BNI | 145 | (65.5–319) | 0.62 | (0.33–1.19) | 180 | (43.2–752) |
| δ Ligands | ||||||
| DPDPE | 2916 | (1612–5246) | 16200 | (1232–21300) | 5.67 | (1.28–25.2) |
| Deltorphin | 3971 | (2448–6443) | 16530 | (1236–22100) | 3.65 | (1.27–10.6) |
| NTI | 13940 | (4448–43720) | 7.02 | (3.65–15.9) | 2.48 | (1.07–5.79) |
CI, confidence interval.