IC50 | |||
---|---|---|---|
NVP-ABE171 | Ariflo | V 11294A | |
nM | |||
Eosinophil function | |||
Oxidative burst (IgG) | 6.0 ± 0.2 (4) | 104.7 ± 5.3 (3) | 712 ± 19 (3) |
T-Cell cytokines release | |||
INF-γ (anti-CD3) | 10.0 ± 0.2 (5) | 257.1 ± 7.6 (4) | 1905 ± 63 (3) |
IL-4 (anti-CD3) | 16.6 ± 0.3 (5) | 389.0 ± 8.5 (4) | 2089 ± 51 (3) |
IL-5 (anti-CD3) | 28.2 ± 0.5 (5) | 199.5 ± 9.2 (4) | 2754 ± 94 (3) |
Monocytes cytokine release | |||
TNF-α (IFN-γ +LPS) | 67.6 ± 1.0 (3) | 3467 ± 64 (3) | 4365 ± 49 (3) |
Data are expressed as mean ± S.E.M. from the number of experiments indicated in parentheses.