Studies | Animals | Drugs | Ischemic Time | Results |
---|---|---|---|---|
min | ||||
Baczko et al. (1997) | Rat | KATP agonist (pinacidil, cromakalim) | 6 | Inhibition |
KATP antagonist (glibenclamide) | No effect | |||
Rioufol et al. (1997) | Pig | KATP antagonist (glibenclamide) | 40 | No effect |
Kita et al. (1998) | Rat | Mit-KATP antagonist (5-HD) | 5 | Inhibition |
Wirth et al. (1999) | Pig | Sar-KATP antagonist (HMR 1883) | 20 | No effect |
This study | Dog | Sar-KATP antagonist (HMR 1098) | 60 | Enhancement4-a |
5-HD, 5-hydroxydecanoate; mit-KATP, mitochondrial ATP-sensitive K+; Sar-KATP, sarcolemmal ATP-sensitive K+.
↵4-a HMR 1098 shows enhancement of reperfusion arrhythmias only in the presence of estradiol, and the drug per se did not show proarrhythmic effect compared with that in the control group as mentioned in the text.