Compound Injected | Number of Mice Surviving/Injected | Survival |
---|---|---|
% total | ||
None | 5 /30 | 16 |
6-1-10 | 24 /29 | 82 |
6-1-2 | 24 /24 | 100 |
Male Swiss mice weighing 25 to 35 g were used. Peptoids were injected intraperitoneally 10 min before ammonium injection. Ammonium acetate (14 mmol/kg) was also injected intraperitoneally. The concentrations of the solutions were adjusted to reach the desired dose by injecting 3 μl per gram of body weight. The number of surviving mice was counted 24 h after ammonium injection. All animals surviving at this time remained alive for several weeks until they were sacrificed.