Table 2

Effect of eprosartan (EPRO 60 mg/kg/day) on kidney histopathology of SHR-SP fed HFD

	Normal Diet		HFD
	WKY	SHR-SP	SHR-SP	SHR-SP EPRO
Kidney crude score	0.17 ± 0.08^2-150 ^2-151	0.72 ± 0.09^2-151	2.42 ± 0.04^2-150	0.24 ± 0.11^2-150 ^{,^2-151}
Total active renal damage	3 ± 2^2-150 ^{,^2-151}	20 ± 6^2-151	195 ± 6^2-150	5 ± 2^2-150 ^{,^2-151}
Arterial necrosis thrombosis	0 ± 0^2-151	0.5 ± 0.4^2-151	58.8 ± 3.6^2-150	0.2 ± 0.2^2-151
Arterial proliferation	0 ± 0^2-150 ^{,^2-151}	6.4 ± 3.9^2-151	24.4 ± 3.6^2-150	0.6 ± 0.3^2-150 ^{,^2-151}
Glomerular lesions, total	0.8 ± 0.5^2-150 ^{,^2-151}	8.8 ± 2.7^2-151	76.5 ± 7.0^2-150	1.4 ± 1.0^2-150 ^{,^2-151}
Glomerular lesions, ischemic	0 ± 0^2-151	1.9 ± 1.1^2-151	55.1 ± 6.3^2-150	0 ± 0^2-151
Tubular regeneration	0.25 ± 0.25^2-150 ^{,^2-151}	1.3 ± 0.3^2-151	27.3 ± 2.9^2-150	0 ± 0^2-150 ^{,^2-151}
Foci of interstitial nephritis	0.5 ± 0.3^2-150 ^{,^2-151}	4.9 ± 1.0	8.5 ± 1.2	1.0 ± 0.4^2-150 ^{,^2-151}
Total tubular casts	1.0 ± 1.0^2-150 ^{,^2-151}	21 ± 5^2-151	349 ± 45^2-150	4 ± 3^2-150 ^{,^2-151}
Foci of renal fibrosis, total	5.9 ± 0.7^2-151	7.4 ± 0.4^2-151	16.4 ± 1.4^2-150	7.1 ± 0.3^2-151
Foci of renal fibrosis, pathological	0 ± 0^2-151	0 ± 0^2-151	11.1 ± 1.1^2-150	0 ± 0^2-151

n = 8 to 9 per group