Acquisition-Recall Interval | Acquisition | Recall | Discrimination ratio | ||
---|---|---|---|---|---|
tO1a | tO1b | tO1(Familiar) | tO2 (Novel) | ||
h | % | ||||
1 | 4.6 ± 1.0 | 4.2 ± 1.2 | 2.4 ± 0.7 | 7.0 ± 2.14-151 | 71.3 ± 8.84-150 |
4 | 5.4 ± 1.2 | 3.8 ± 0.7 | 5.4 ± 0.9 | 6.7 ± 0.8 | 56.5 ± 4.4 |
8 | 4.2 ± 0.7 | 3.9 ± 0.7 | 5.3 ± 0.6 | 5.9 ± 0.8 | 52.6 ± 1.8 |
24 | 5.1 ± 1.0 | 4.8 ± 1.3 | 6.1 ± 1.3 | 5.4 ± 1.0 | 51.0 ± 3.6 |
In a first trial (acquisition), mice were exposed to two identical objects (O1a and O1b) for 3 min, and in a second trial (recall), to two dissimilar objects, a familiar (O1) and a novel one (O2), for 3 min. Results are expressed as mean ± S.E.M. of 10 mice/group. Discrimination ratio = [tO2/(tO1+tO2)] × 100.