Compounds | Step-Through Latency | % Change from Vehicle Control |
---|---|---|
mg/kg i.p. | s | % |
Vehicle | 141.3 ± 17.2 | |
UK 14304 0.04 | 125.4 ± 23.3 | −11.3 |
UK 14304 0.16 | 122.0 ± 19.3 | −13.7 |
UK 14304 0.63 | 53.0 ± 17.81-160 | −62.5 |
UK 14304 1.25 | 43.1 ± 18.61-165 | −69.5 |
Vehicle | 160.1 ± 19.9 | |
Scopolamine 0.16 | 125.5 ± 27.1 | −21.6 |
Scopolamine 0.63 | 71.4 ± 24.71-150 | −55.4 |
Scopolamine 2.5 | 34.8 ± 20.81-160 | −78.3 |
Vehicle | 180.0 ± 0.0 | |
Diazepam 0.16 | 159.0 ± 15.0 | −11.7 |
Diazepam 0.63 | 144.5 ± 18.6 | −19.7 |
Diazepam 2.5 | 105.8 ± 22.51-150 | −41.2 |
Diazepam 10 | 78.2 ± 22.51-160 | −56.6 |
Diazepam 20 | 46.9 ± 18.11-165 | −73.9 |
Diazepam 40 | 29.3 ± 13.81-165 | −83.7 |
Compounds were administered (i.p.) 30 min before the initial trial (training). Animals were trained with a single electric footshock of 0.8 mA/2 s and were tested 48 h later. Results are mean ± S.E.M. of 12 rats.