Table 1

Effect of DIDS, BSP, and DPC on IL-12 p40 production in J774 macrophages

Drug	IL-12
	% of control
Control	100 ± 1.7
10 μM DIDS	94 ± 1.9^1-150
50 μM DIDS	47 ± 5.2^**
100 μM DIDS	14.6 ± 1^**
500 μM DIDS	0 ± 0^**
10 μM BSP	94 ± 2^1-150
50 μM BSP	57 ± 2^**
100 μM BSP	28 ± 0.2^**
500 μM BSP	5.8 ± 0.1^**
300 μM DPC	142 ± 18^1-150
1000 μM DPC	179 ± 24^**

DIDS and BSP suppress and DPC enhances IL-12 p40 production in J774 macrophages stimulated with 10 μg/ml LPS and 100 U/ml IFN-γ. Data are expressed as the mean ± S.E.M. of six wells.

↵1-150 p < 0.05; **p < 0.01.