Table 2

Morphometric analysis of iliofemoral artery lesions obtained 28 days following balloon injury in hypercholesterolemic rabbits

Morphometric ParameterVehicle (n = 16)SB 239063 (n = 18)
5% β-cyclodextrin50 mg/kg/day, p.o.
EEL circumference (mm)5.70  ± 0.105.67  ± 0.6
Lumen circumference (mm)3.40  ± 0.143.88  ± 0.162-150
Avg. wall thickness (mm)0.37  ± 0.020.30  ± 0.022-150
Avg. NI thickness (mm)0.23  ± 0.200.16  ± 0.012-160
NI area (mm2)0.89  ± 0.080.63  ± 0.062-150
Media area (mm2)0.75  ± 0.030.73  ± 0.06
NI/medium1.23  ± 0.110.92  ± 0.082-150
Wall area (mm2)1.63  ± 0.101.36  ± 0.122-150
Wall/lumen2.57  ± 0.511.38  ± 0.142-150

All values are the mean ± S.E.M. The vehicle was 5% 2-hydroxypropyl-β-cyclodextrin.

  • EEL, external elastic lamina; NI, neointima.

  • ↵2-150  p < 0.05;

  • ↵2-160  p< 0.01.