Table 1

The percentage of remaining uptakes of organic anion by hOCTs and organic cation by hOCTs in the presence of ACV, GCV, and AZT

ACVGCVAZT
hOAT167.0 ± 2.051-150 87.1 ± 1.60** 30.7 ± 0.761-150
hOAT299.5 ± 1.2363.3 ± 4.041-150 76.7 ± 2.511-150
hOAT364.3 ± 2.751-150 74.3 ± 4.271-150 70.0 ± 2.591-150
hOAT492.5 ± 1.0289.9 ± 6.8084.2 ± 2.18***
hOCT188.4 ± 2.4*** 88.3 ± 2.4*** 99.3 ± 4.3
hOCT291.8 ± 6.3104.5 ± 11.6101.2 ± 5.6

S2 hOAT1, S2 hOAT2, S2 hOAT3, S2 hOAT4, S2 hOCT1, and S2 hOCT2 were incubated at 37°C in solution containing either 5 μM [14C]PAH for 2 min (hOAT1), 5 nM [3H]PGF for 1 min (hOAT2), 50 nM [3H]estrone sulfate for 2 min (hOAT3 and hOAT4), or 5 μM [14C]TEA for 5 min (hOCT1 and hOCT2) in the absence or presence of 1 mM ACV, GCV, or AZT. Each value represents the mean ± S.E. of four determinations.

  • 1-150P < 0.001, ** P < 0.01, and *** P < 0.05 vs. control.