Organ | Blood | Lung | Liver | Kidney | Spleen | Heart |
---|---|---|---|---|---|---|
Weight, g | 220 | 25 | 53 | 37 | 12 | 11 |
Anti-PECAM | 11.1 ± 2.1 | 18.8 ± 2.3 | 6.9 ± 0.5 | 0.4 ± 0.1 | 5.2 ± 0.4 | 0.2 ± 0.1 |
IgG | 40.7 ± 4.5 | 1.3 ± 0.2 | 3.2 ± 0.5 | 0.9 ± 0.1 | 1.9 ± 0.4 | 0.2 ± 0.1 |
A mixture of 125I-labeled anti-PECAM/SA and131I-labeled IgG was injected in the anesthetized pigs and the uptake of isotopes in organs was determined in a gamma counter. Average size of the internal organs in 3-kg pigs is shown in the first row; the total weight of blood was calculated as 7% of body weight. The data are presented as absolute values of isotopes uptake in organs, percentage of injected dose, mean ± S.E.M., n = 3–7.