PVN CRF mRNA response to chronic variable stress: effect of venlafaxine treatment
| Brain Region | Saline | Saline + Stress | Venlafaxine | Venlafaxine +Stress |
|---|---|---|---|---|
| PVN | 100 ± 7 (8) | 129 ± 6 (7) | 114 ± 7 (9) | 92 ± 12 (8)2-150 |
| CeA (left) | 100 ± 9 (6) | 96 ± 12 (7) | 80 ± 18 (7) | 119 ± 6 (8) |
| Dorsolateral BNST | 100 ± 6 (7) | 97 ± 8 (7) | 117 ± 9 (7)2-150 | 116 ± 11 (7) |
| Ventral BNST | 100 ± 7 (7) | 92 ± 6 (7) | 94 ± 9 (7) | 92 ± 5 (7) |
Rats received 26-day venlafaxine (30 mg/kg/day) or saline treatment and received either no stress or chronic variable stress during the last 2 weeks. CRF mRNA expression was determined in the indicated regions by in situ hybridization histochemistry; results are given as mean percentage of control ± S.E.M. (n).
↵2-150 P < 0.05, two-way ANOVA for drug-stress interaction in the PVN, venlafaxine effect in the dorsolateral BNST.