Pharmacokinetic parameters of grepafloxacin and levofloxacin after intravenous administration in rats
| Grepafloxacin | Levofloxacin | |||
|---|---|---|---|---|
| Control | +Cyclosporin A | Control | +Cyclosporin A | |
| CL (ml/min) | 10.8 ± 0.8 | 6.5 ± 0.51-150 | 3.85 ± 0.14 | 3.31 ± 0.24 |
| V 1 (liters) | 0.84 ± 0.07 | 0.71 ± 0.08 | 0.21 ± 0.01 | 0.21 ± 0.01 |
| Q(ml/min) | 29.3 ± 2.9 | 22.1 ± 1.7 | 8.01 ± 0.65 | 7.14 ± 0.99 |
| V ss(liters) | 2.35 ± 0.30 | 1.50 ± 0.171-150 | 0.53 ± 0.03 | 0.47 ± 0.03 |
Grepafloxacin or levofloxacin was injected at a dose of 10 mg/kg at 5 min after intravenous administration of saline (control) or cyclosporin A (30 mg/kg). Each value represents the mean ± S.E. of four to five rats.
↵1-150 P < 0.05, significantly different from control.