Michaelis-Menten kinetic parameters of amodiaquineN-desethylation and inhibition Ki values of AQ metabolism by quercetin in HLMs and CYP2C8 expressed in human lymphoblastoid cell lines vs. yeast
| Microsomes | Vmax | Km | CLint | Ki |
|---|---|---|---|---|
| HLM | 1462 | 2.4 | 608.2 | 1.56 |
| CYP2C8Lymphoblastoid cell lines | 2.6 | 1.2 | 2.1 | 1.96 |
| CYP2C8Yeast | 3.9 | 0.9 | 4.4 | 2.35 |
Vmax data shown are in units of picomoles per minute per milligram for HLMs and picomoles per minute per picomole for CYP2C8; CLint data shown are in units of microliters per minute per milligram for HLMs and microliters per minute per picomole for CYP2C8; Km and Ki data shown are in units of micromoles.