Ontogeny of human hepatic phase I DME
| Gene | Prenatal Trimester | Neonate | 1 Month to 1 Year | 1 to 10 Years | Adult | ||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | |||||
| CYP1A1 | + | + | ? | − | − | − | − |
| CYP1B1 | ? | ±? | ? | ? | − | − | − |
| CYP1A2 | − | − | − | − | + | + | + |
| CYP2A | − | − | − | ? | + | + | + |
| CYP2B6 | − | − | ? | ? | ? | + | + |
| CYP2C | − | − | − | + | + | + | + |
| CYP2D6 | − | ± | ± | + | + | + | + |
| CYP2E1 | ? | +? | +? | + | + | + | + |
| CYP2J | ? | + | ? | ? | ? | + | + |
| CYP3A7 | + | + | + | + | − | − | − |
| CYP3A4/3A5 | − | − | − | + | + | + | + |
| FMO1 | + | + | + | − | − | − | − |
| FMO3 | ± | − | − | ± | + | + | + |
| ADH1 | + | + | + | + | − | − | − |
| ADH2 | − | + | + | + | + | + | + |
| ADH3 | − | − | + | + | + | + | + |
+, activity or protein detectable; −, no detectable activity or protein; ?, not determined; ±, activity or protein detectable, but in only a fraction of the samples examined; +?, presence or absence is controversial.