Effects of a mixture of peptidase inhibitors on NC and [Arg14,Lys15]NC actions in the electrically stimulated rat vas deferens
| Control | Peptidase Inhibitors | |||
|---|---|---|---|---|
| pEC50 (CL 95%) | Emax | pEC50 (CL 95%) | Emax | |
| % | % | |||
| NC | 7.07 (0.24) | 78 ± 3 | 7.63 (0.23)3-150 | 91 ± 33-150 |
| [Arg14,Lys15]NC | 7.98 (0.32) | 81 ± 4 | 8.19 (0.35) | 93 ± 23-150 |
Peptidase inhibitors are as follows: amastatin, bestatin, phosphoramidon, and captopril, all at 30 μM. The data are means ± S.E.M. (E max values) or CL 95% (pEC50values) of at least four experiments.
CL, confidence limits.
↵3-150 p < 0.05 vs. control (Student'st test).