Toxicity of TMTX + nucleoside transport inhibitor (NTI) in normal FVB/N mice
| Drug Dose | Fraction of Mice Surviving for 14 Days |
|---|---|
| mg/kg | |
| 40 TMTX | 3 /3 |
| 40 TMTX +NTI2-a | 2 /3 |
| 60 TMTX | 1 /3 |
| 60 TMTX + NTI2-a | 0 /3 |
Survival of mice administered TMTX with or without NBMPR-P (n = 3) was determined. Mice were administered drug for 5 days as described in the text. The experiment was ended at 16 days.
↵2-a NBMPR-P (20 mg/kg) was administered in addition to TMTX.