Agonist (pmol, i.t.) | ED50 Delt II (95% CL) | ED50 Mox (95% CL) |
---|---|---|
α2AWT | ||
Observed combination | 0.16 (0.12–0.2)1-150 | 0.027 (0.021–0.034)1-150 |
Theoretical additive | 0.8 (0.59–1) | 0.13 (0.099–0.17) |
D79N-α2A | ||
Observed combination | 0.026 (0.03–0.48)1-150 | 0.01 (0.001–0.019)1-150 |
Theoretical additive | 3.1 (2.1–4.1) | 1.2 (0.82–1.6) |
Delt II, deltorphin II; i.t., intrathecal; Mox, moxonidine.
↵1-150 Significant difference from theoretical additive by Student's t test (p < 0.05) confirming synergism.