Physiochemical and metabolic stability of the two peptides
| SAM 995 | SAM 1095 | |
|---|---|---|
| Octanol/saline D value (± S.E.) | 2.82 ± 0.22 | 0.25 ± 0.052-160 |
| % Binding to BSA in Ringer's solution | 40 | 36 |
| Metabolic t 1/2 serum (mouse) | 118 min | >500 |
| Metabolic t 1/2 brain (mouse) | 312 min | >500 |
| Metabolic t 1/2 serum (rat) | 89 min | 164 |
| Metabolic t 1/2 brain (rat) | 331 min | >500 |
↵2-160 Significantly different at p < 0.01 by using Student's t test.