Table 2

Potential kinases that phosphorylate eNOS

Kinase	Site	Agonists	eNOS Activity	References
Akt	S1177/1179	VEGF, IGF, shear stress, estrogen, simvastatin	↑	Dimmeler et al., 1999; Fulton et al., 1999; Gallis et al., 1999; Michell et al., 1999
AMPK	S1177,^2-aT495	[AMP]_i	↑^2-a	Chen et al., 1999
PKC	T495	PMA	↓	Michell et al., 1999
PKA	S1177, S633	Iloprost	↑	Butt et al., 2000
PKG	S1177, S633	N.D.	↑	Butt et al., 2000
?	S116	Shear stress	?	Gallis et al., 1999
MAP kinase	? (not 1177)	Bradykinin	↓	Bernier et al., 2000

N.D., not determined.
↵2-a In the presence of CaM/Ca²⁺.