Table 6

Attenuation of the cage-leaving response and potentiation of the wet-dog shake response

Test Compound	Dose mg/kg	Cage-Leaving Response		Wet-Dog Shake Response
Test Compound	Dose mg/kg	No. Rats Leaving	Leaving Time Median^6-a	No. Rats Responding	Shakes/Rat/h Mean ± S.E.M.
			min
Controls	2 ml/kg	46 /50	2.90 (2.00)	30 /30	6.0 ± 0.22
Saline	2 ml/kg	2 /40	>12
8-OH-DPAT	0.1 s.c.	2 /10	12
	0.3 s.c.	10 /10	0.48 (1.05)^6-165	10 /10	18.3 ± 0.73^6-167
	1 s.c.	9 /10	3.30 (2.89)^6-165
NAE-086	0.3 s.c.	1 /10	>12	10 /10	7.4 ± 1.20
	1 s.c.	7 /10	4.28 (5.81)^6-160	9 /10	7.8 ± 0.22
	3 s.c.	7 /10	2.90 (5.60)^6-160	10 /10	6.7 ± 0.42
	10 s.c.	10 /10	1.75 (1.76)^6-165	5 /5	10.8 ± 1.5^6-159
NAE-086	1 p.o.	2 /10	12 (2.95)	10 /10	6.2 ± 0.60
	3 p.o.	7 /10	3.40 (5.58)^6-160	10 /10	7.5 ± 0.64
	10 p.o.	8 /10	1.92 (4.40)^6-165	10 /10	19.0 ± 1.1^6-167
Buspirone	0.3 s.c.	2 /10	12 (1.43)
	1 s.c.	8 /10	0.72 (4.79)^6-165	5 /5	20.2 ± 3.90^6-159
	3 s.c.	8 /10	4.80 (5.20)^6-165

The rats (ALAB Sprague-Dawley strain) were treated with test compounds 24 h before administration of 8-OH-DPAT (0.06 mg/kg s.c.). Controls were treated and challenged with saline.

6-150 p < 0.05;
↵6-160 p < 0.01;
↵6-165 p < 0.001 vs. saline (Mann-WhitneyU test).
↵6-159 p < 0.05;
↵6-167 p < 0.01 vs. controls (Dunnett's multiple comparison test).
↵6-a Medians (± quartiles) were calculated according to Snedecor and Cohran (1967).