IC50 values of NCS-382 and GHB using [3H]NCS-382 (16 nM) as a radioligand in the rat cerebral cortex and hippocampus membranes
| Drug | IC50 (μM) | |
|---|---|---|
| Cerebral cortex (n) | Hippocampus (n) | |
| NCS-382 | 1.8 ± 0.08 (7) | 2.3 ± 0.15 (5) |
| GHB | 25 ± 1.8 (5) | 23 ± 3.2 (3) |
Each value is mean ± S.E.M. of number of individual experiments indicated (n), and each experiment was performed in triplicate.