Drug | Cells | Exp. | Plates | Model | IC50Eq. | Parameter | Estimates | γ Eq. | Parameter | Estimates | Plateau Eq. | Parameter | Estimates |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHS 828 | U937 GTB | 3 | 23 | 1a | 2c | IC50back | 0.903 ± 0.136 | 3b.I | γ0 | −8.83 ± 0.1.47 | Econ | 106 ± 1 | |
IC50max | 0.016 ± 0.005 | γ1 | −1.0 ± 0.4 | B | 10.7 ± 1.1 | ||||||||
T50 | 25.5 ± 3.3 | γ2 | −6.67 ± 1.74 | ||||||||||
S | 13.3 ± 6.8 | ||||||||||||
CHS 828 | MDA 231 | 2 | 15 | 1a | 2c | IC50back | 2.05 ± 0.06 | 3a | γ0 | −5.15 ± 0.22 | Econ | 101 ± 0.02 | |
IC50max | 0.08 ± 0.24 | B | 32.5 ± 0.1 | ||||||||||
T50 | 29.2 ± 0.1 | ||||||||||||
S | 9.57 ± 0.31 | ||||||||||||
CHS 828 | 8226/S | 1 | 7 | 1a | 2c | IC50back | 2.56 ± 0.47 | 3b.I | γ0 | −2.52 ± 0.59 | Econ | 117 ± 5 | |
IC50max | 0.078 ± 0.0001 | γ1 | −1.62 ± 0.05 | B | 0.00 | ||||||||
T50 | 24.5 ± 1.3 | γ2 | −13.2 ± 0.1 | ||||||||||
S | 6.99 ± 0.32 | ||||||||||||
CHS 828 | CLL | 1 | 5 | 1a | 2c | IC50back | 0.372 ± 0.011 | 3b.II | γ0 | −2.34 ± 0.02 | Econ | 102 ± 0.03 | |
IC50max | 0.004 ± 0.091 | γ1 | −0.436 ± 0.480 | B | 9.9 ± 0.1 | ||||||||
T50 | 23.7 ± 0.02 | γ2 | −2.13 ± 0.51 | ||||||||||
S | 17.2 ± 0.1 | ||||||||||||
Paclitaxel | U937 GTB | 2 | 15 | 1a | 2b | K | 0.175 ± 0.035 | 3b.I | γ0 | −0.771 ± 0.233 | Econ | 110 ± 2 | |
n | fixed to 1 | γ1 | −3.34 ± 0.52 | B | 1.9 ± 0.4 | ||||||||
γ2 | −12.5 ± 2.7 | ||||||||||||
Etoposide | U937 GTB | 2 | 15 | 1a | 2c | IC50back | 2.584 ± 0.272 | 3a | γ0 | −1.78 ± 0.05 | Econ | 110 ± 0.04 | |
IC50max | 0.129 ± 0.136 | B | 0.00 | ||||||||||
T50 | 4.12 ± 0.14 | ||||||||||||
S | 2.99 ± 0.17 | ||||||||||||
Topotecan | U937 GTB | 2 | 15 | 1b | 2c | IC50back | 0.101 ± 0.011 | 3b.I | γ0 | −0.48 ± 0.15 | Econ | 1002-b ± 0.1 | |
IC50max | 0.025 ± 0.001 | γ1 | −3.11 ± 0.74 | 4a | Econ1 | 95.6 ± 10. | |||||||
T50 | 17.2 ± 3.3 | γ2 | −3.23 ± 0.61 | ke | 0.14 ± 0.02 | ||||||||
S | 11.1 ± 6.4 | γb | −5.65 ± 4.54 | B | 1 ± 0.1 | ||||||||
2a | IC50b | 132.8 ± 5.1 |
2-a Units: IC50back, IC50max, and IC50b are expressed in micromolar range; T50 is expressed in hours; K is expressed in micromolar hours; γ0, γ1, γ2, γb, S are unitless; and Econ, GROW, Econb, Econ1, and B are expressed as percentages. ke is expressed in hours−1.
↵2-b GROW = 18.5 ± 2.8 at C ≤ 0.0289 μM and if C < 0.0004 then GROW = 0.