Effects of triazolam on NREM sleep cycles
| Substance | Dose | Injection Time | n | Duration of NREMS Episodes (min) | Number of NREMS Episodes | Latency of Sleep (min) | ||
|---|---|---|---|---|---|---|---|---|
| Dark Period | Light Period | Dark Period | Light Period | |||||
| mg/kg | ||||||||
| Triazolam | 0 | 9:00 AM | 8 | 1.82 ± 0.14 | 2.53 ± 0.13 | 98.6 ± 8.2 | 160.0 ± 6.8 | 18.4 ± 2.4 |
| 0.5 | 9:00 AM | 1.80 ± 0.08 | 2.60 ± 0.06 | 97.8 ± 8.1 | 152.8 ± 4.9 | 25.2 ± 5.5 | ||
| Triazolam | 0 | 9:00 AM | 8 | 1.78 ± 0.07 | 2.68 ± 0.11 | 94.0 ± 8.0 | 149.5 ± 6.2 | 23.9 ± 1.9 |
| 1.5 | 9:00 AM | 1.88 ± 0.09 | 3.03 ± 0.165-150 | 89.4 ± 9.6 | 141.0 ± 7.1 | 16.4 ± 1.45-150 | ||
| Triazolam | 0 | 9:00 AM | 10 | 1.71 ± 0.05 | 2.89 ± 0.18 | 90.5 ± 4.7 | 146.4 ± 7.5 | 19.0 ± 1.5 |
| 4.5 | 9:00 AM | 1.75 ± 0.05 | 3.41 ± 0.205-150 | 89.5 ± 4.7 | 133.3 ± 6.75-150 | 17.2 ± 2.5 | ||
The number and length of the episodes were determined using a computer program with the criterion that each episode lasted at least 30 sec. All values are expressed as means ± S.E.
↵5-150 P < 0.05 versus vehicle treatment.