Table 2

Comparison of ligand affinities determined by competition binding (KI) or isolated tissue experiments (KB) in pig coronary arteries

AntagonistKIKBKB/KI
nM nM
[N-benzoyl]hα-CGRP8–37 0.272-a 40.362-a 149
[N-acetyl]hα-CGRP8–37 1.3  ± 0.829.22-a 22
hα-CGRP8–37 6.6  ± 6.34,6702-b 707
[D-Pen2,7]hα-CGRP21.0  ± 5.9629  ± 94.32-c 30
[Cha37]hα-CGRP8–37 32.7  ± 13.69,528  ± 1,1562-d 291
[Ala37]hα-CGRP8–37 499.9  ± 265205,589  ± 34,5002-d 411

Unless indicated otherwise, KI values were from the data in Table 1.

  • ↵2-a  Smith et al. (2001).

  • ↵2-b  Waugh et al. (1999).

  • ↵2-c  Saha et al. (1998).

  • ↵2-d  D. J. J. Waugh, personal communication.