Ligand | Vehicle | MDL 11,939 | Bmax | ||
---|---|---|---|---|---|
Kd | Bmax | Kd | Bmax | ||
nM | fmol/mg tissue | nM | fmol/mg tissue | % Increase | |
[125I]DOI | 0.54 ± 0.05 | 3.12 ± 0.22 | 0.63 ± 0.08 | 6.26 ± 0.315-a | 1005-a |
[3H]Ketanserin | 0.50 ± 0.07 | 13.9 ± 1.4 | 0.48 ± 0.04 | 21.7 ± 1.35-a | 565-a |
Rabbits were treated once daily for 8 days with MDL 11,939 (10 μmol/kg). Twenty-four hours after the last treatment, the cortical 5-HT2A receptors were measured. The values (mean ± S.E.M.) are derived from Scatchard analysis by using five animals per treatment.
↵5-a A significant difference from the corresponding vehicle-treated control (p < 0.05).