Table 2

Mean (and S.E.M.) peak change from baseline for all subjective, psychomotor, and physiological effects for all main effects of infusion duration and dose conditions

Outcome Measure	Infusion Duration^2-150		Dose^2-160
Outcome Measure	60 min	15 min	Bolus	Placebo (Mean)	5 mg/70 kg	10 mg/70 kg
Visual analog scales
Drug Effect	23.83 (4.69)^a	35.42 (4.17)^b	53.86 (5.01)^c	4.94 (1.03)^a	32.67 (3.95)^b	42.74 (4.19)^c
Liking	13.75 (4.09)^a	27.56 (4.80)^b	29.33 (5.02)^b	1.00 (1.89)^a	17.91 (3.62)^b	29.19 (4.02)^c
High	19.25 (3.97)^a	24.47 (5.14)^a	34.19 (4.48)^b	4.00 (0.90)^a	18.28 (3.52)^b	33.67 (3.77)^c
Good	16.58 (3.40)^a	29.58 (4.59)^b	33.78 (4.47)^b	1.89 (1.05)^a	19.93 (3.10)^b	33.37 (3.72)^c
Bad	14.78 (4.41)^a	15.42 (3.45)^a	35.14 (5.21)^b	3.70 (1.22)^a	19.69 (3.86)^b	23.87 (3.75)^b
Sick	5.97 (1.92)^a	10.64 (3.53)^a ^b	16.58 (3.81)^b	2.28 (0.86)^a	7.89 (2.44)^a ^b	14.24 (2.81)^b
Adjective Rating Scales
Agonist	10.19 (2.68)^a	15.36 (2.35)^b	17.81 (2.80)^b	1.78 (1.56)^a	10.15 (2.02)^b	18.76 (2.16)^c
Antagonist	7.17 (2.24)^a	5.83 (1.20)^a	7.28 (1.63)^a	3.89 (1.03)^a	5.24 (1.15)^a ^b	8.28 (1.62)^b
ARCI
LSD	1.75 (0.41)^a	2.08 (0.50)^a	3.36 (0.39)^b	0.83 (0.20)^a	1.93 (0.39)^b	2.87 (0.32)^c
PCAG	2.78 (0.59)^a	3.36 (0.51)^a	2.64 (0.62)^a	1.41 (0.34)^a	2.76 (0.45)^b	3.09 (0.49)^b
MBG	0.36 (0.63)^a	0.19 (0.65)^a	1.53 (0.60)^a	−0.74 (0.31)^a	−0.13 (0.51)^a	1.52 (0.49)^b
BENZ	−1.31 (0.40)^a	−1.50 (0.41)^a	−0.86 (0.48)^a	−0.59 (0.25)^a	−1.26 (0.33)^a	−1.19 (0.37)^a
A	1.06 (0.34)^a	0.28 (0.44)^a	0.81 (0.37)^a	−0.17 (0.20)^a	0.17 (0.33)^a	1.26 (0.29)^b
Psychomotor Performance
Number Attempted	−4.67 (1.76)^a	−1.39 (1.86)^a	−1.00 (1.44)^a	2.07 (1.44)^a	1.44 (1.42)^a	−6.15 (1.16)^b
Number Correct	−5.31 (1.85)^a	−1.94 (1.95)^a	−3.78 (2.04)^a	2.44 (1.64)^a	−0.37 (1.59)^a	−6.98 (1.46)^b
Physiological Measures
Pupil Diameter	−2.67 (0.43)^a	−2.98 (0.30)^a	−3.47 (0.30)^a	−0.93 (0.29)^a	−2.60 (0.22)^b	−3.48 (0.33)^c
Respiration Rate	−2.39 (0.69)^a	−2.19 (0.83)^a	−2.19 (0.89)^a	−0.06 (0.57)^a	−1.44 (0.65)^a ^b	−3.07 (0.64)^b
Oxygen Saturation	−0.64 (0.43)^a	0.11 (0.37)^a	−0.83 (0.38)^a	0.15 (0.31)^a	−0.11 (0.32)^a	−0.80 (0.33)^a
Heart Rate	−5.08 (1.46)^a	−5.61 (1.91)^a	−2.31 (1.87)^a	−4.37 (1.46)^a	−6.26 (1.32)^a	−2.41 (1.51)^a
Systolic Blood Pressure	−2.08 (2.56)^a	3.03 (2.53)^a	−3.36 (2.89)^a	−1.15 (2.47)^a	−0.65 (2.21)^a	−0.96 (2.18)^a
Diastolic Blood Pressure	−6.83 (2.23)^a	−2.56 (2.80)^a	−2.50 (2.38)^a	2.67 (1.93)^a	−5.98 (1.96)^a	−1.94 (2.08)^a
Skin Temperature	−0.41 (1.02)^a ^b	−2.09 (1.05)^a	2.23 (0.88)^b	−2.86 (0.81)^a	0.55 (0.92)^b	−0.73 (0.74)^b
Plasma Levels (in nmol/l)
Morphine	102 (7)^a	217 (17)^b	684 (75)^c	not detectable	206 (22)^a	462 (62)^b
M3G	277 (20)^a	271 (18)^a	280 (20)^a	not detectable	179 (5)^a	373 (10)^b
M6G	46.9 (3.4)^a	46.2 (2.9)^a	44.9 (3.1)^a	not detectable	29.8 (0.7)^a	62.1 (1.7)^b

↵2-150 Means sharing a common superscript letter are not significantly different (Fisher's least significant difference,p < 0.05). All data refer to mean (and S.E.M.) peak change from baseline.
↵2-160 Means presented correspond to active doses of morphine (5 mg/70 kg and 10 mg/70 kg).