Table 4

Time course of the effects of i.v. administration of Rec 15/3079, WAY 100635, and indomethacin on BVC (in milliliters) in conscious rats with bladders infused with diluted acetic acid

Treatment (mg/kg)	No. of rats	−60 min (Basal I)	0 min (Basal II)	15 min	30 min	45 min	60 min	Percent change vs. Basal II at
Treatment (mg/kg)	No. of rats	−60 min (Basal I)	0 min (Basal II)	15 min	30 min	45 min	60 min	15	30	45	60
								min
Vehicle	7	0.67 ± 0.11	0.32 ± 0.05^4-164	0.29 ± 0.04	0.21 ± 0.04^4-160	0.22 ± 0.04^4-160	0.18 ± 0.03^4-160	−10	−32	−31	−42
Rec 15/3079 (0.3)	7	0.62 ± 0.05	0.24 ± 0.03^4-164	0.30 ± 0.04	0.29 ± 0.03	0.24 ± 0.03	0.22 ± 0.03	22	19	−1	−12
p within times				<0.01	<0.01	<0.05	N.S.
Vehicle	6	0.56 ± 0.07	0.30 ± 0.04^4-151	0.24 ± 0.04	0.25 ± 0.04	0.24 ± 0.05	0.19 ± 0.04	−21	−15	−18	−33
WAY 100635 (0.3)	5	0.66 ± 0.18	0.29 ± 0.09^4-151	0.30 ± 0.07	0.31 ± 0.06	0.23 ± 0.05	0.19 ± 0.05^4-160	6	10	−18	−34
pwithin times				<0.05	<0.05	N.S.	N.S.
Vehicle	7	0.49 ± 0.04	0.27 ± 0.04^4-164	0.24 ± 0.04	0.20 ± 0.04^4-150	0.21 ± 0.03	0.19 ± 0.04^4-160	−12	−24	−21	−29
Indomethacin (1.0)	6	0.66 ± 0.13	0.28 ± 0.06^4-164	0.24 ± 0.04	0.32 ± 0.05	0.35 ± 0.08^4-150	0.36 ± 0.08^4-150	−16	12	24	26
pwithin times				N.S.	<0.05	<0.05	<0.01

Data represent the mean values ± S.E. of BVC at different times after administration (at time 0, basal II) of vehicle or different doses of the compound.

N.S., not significant.
↵4-151 p < 0.05 and
↵4-164 p < 0.01 vs. basal I values;
↵4-150 = p < 0.05 and
↵4-160 = p < 0.01 vs. “basal II” values (within groups).
4-a “p within times” represents, at each time, the significance of the difference between the trend (basal to time) observed in the saline and compound groups (analysis of variance of contrast variables).