Treatment (mg/kg/min) | No. of rats | 0 min (basal) | 15 min | 30 min | 15 min | 30 min |
---|---|---|---|---|---|---|
% change | ||||||
Saline | 5 | 103 ± 10 | 96 ± 15 | 98 ± 15 | −6 | −5 |
Oxybutynin (0.01) | 8 | 102 ± 11 | 87 ± 133-150 | 75 ± 143-160 | −15 | −27 |
p between treatments3-a | N.S. | N.S. | ||||
Saline | 7 | 67 ± 10 | 58 ± 8 | 54 ± 9 | −13 | −20 |
Oxybutynin (0.03) | 7 | 89 ± 17 | 44 ± 103-160 | 28 ± 63-160 | −51 | −68 |
p between treatments | p < 0.01 | p < 0.01 |
Data represent the mean values ± S.E. of MP before and at 15 and 30 min during i.v. infusion of saline (0.1 ml/kg/min) or compound.
N.S., not significant.
↵3-150 p < 0.05 and
↵3-160 p < 0.01 versus basal values (within groups).
↵3-a “p between treatments” represents, at each time, the significance of the difference between the trend (basal to time) observed in the saline and oxybutynin groups (analysis of variance of contrast variables).